Spider Venom Toxins
نویسندگان
چکیده
منابع مشابه
Extracellular matrix molecules as targets for brown spider venom toxins.
Loxoscelism, the term used to describe lesions and clinical manifestations induced by brown spider's venom (Loxosceles genus), has attracted much attention over the last years. Brown spider bites have been reported to cause a local and acute inflammatory reaction that may evolve to dermonecrosis (a hallmark of envenomation) and hemorrhage at the bite site, besides systemic manifestations such a...
متن کاملBrown Spider (Loxosceles genus) Venom Toxins: Tools for Biological Purposes
Venomous animals use their venoms as tools for defense or predation. These venoms are complex mixtures, mainly enriched of proteic toxins or peptides with several, and different, biological activities. In general, spider venom is rich in biologically active molecules that are useful in experimental protocols for pharmacology, biochemistry, cell biology and immunology, as well as putative tools ...
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A toxin, designated Fvrr has been isolated from the venom of the green mamba Dendroaspis angusticeps by ion exchange chromatography on Amberlite CG-50 and gel filtration on Sephadex G-50. . Toxin FvII consists of 61 amino acid residues, is devoid of phenylalanine and tryptophan, and is cross-linked by four intramolecular disulfide bridges. Immunochemically, toxin FvII is completely distinct fro...
متن کاملPhospholipase D Toxins of Brown Spider Venom Convert Lysophosphatidylcholine and Sphingomyelin to Cyclic Phosphates
Venoms of brown spiders in the genus Loxosceles contain phospholipase D enzyme toxins that can cause severe dermonecrosis and even death in humans. These toxins cleave the substrates sphingomyelin and lysophosphatidylcholine in mammalian tissues, releasing the choline head group. The other products of substrate cleavage have previously been reported to be monoester phospholipids, which would re...
متن کاملIdentification and molecular cloning of insecticidal toxins from the venom of the brown spider Loxosceles intermedia.
The venom of Loxosceles intermedia was investigated for the presence of insecticidal toxins active against Spodoptera frugiperda (Lepdoptera: Noctuidade), an insect that has caused great reductions in corn production in Brazil. A combination of gel filtration (Sephadex G-100) and ion-exchange chromatography (Carboxymethyl Cellulose, CM 52) resulted in four major fractions that were submitted to...
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ژورنال
عنوان ژورنال: Journal of Venomous Animals and Toxins
سال: 2001
ISSN: 0104-7930
DOI: 10.1590/s0104-79302001000200031